What to expect: As the first Ritz-Carlton to open in South America, this hotel offers the company's superb personal service in a fresh setting: Santiago's exclusive El Golf neighborhood. As a result, it's conveniently close to upscale shops, trendy restaurants, and major businesses, yet also provides a refined retreat from the crowded streets of Chile's capital city.

Amenity highlights: From the inlaid marble floor in the lobby to the vaulted glass roof, The Ritz-Carlton, Santiago offers classic design elements with eye-catching style. That's especially true in the glass-enclosed rooftop spa and fitness center—guests can swim, workout, or arrange a massage with a backdrop of views that stretch from the city below to the heights of the Andes, 30 miles away.

Insider tip: For a taste of Chile's best, order a bottle of locally produced Carmenere wine in the Wine 365 Bar. Originally imported from Bordeaux, France, the rare Carmenere grape produces limited quantities of boutique red wines noted for their low tannins and bright blackberry flavor.